Antibiotic-associated pseudomembranous colitis: an epidemiologic investigation of a cluster of cases
| Autor: | P. F. Pierce, James M. Hughes, V. R. Dowell, Robert Fekety, R. Wilson, O. Nunez-Montiel, Joseph Silva, V. F. Garagusi, G. D. Rifkin |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Antibiotics Cephalosporin Enema Gastroenterology Intestinal mucosa Internal medicine medicine Immunology and Allergy Humans Colitis Intubation Gastrointestinal Aged Clostridium business.industry Clindamycin Pseudomembranous colitis Clostridium difficile Middle Aged medicine.disease Anti-Bacterial Agents Cephalosporins Infectious Diseases Aminoglycosides Surgical Procedures Operative Etiology Female business medicine.drug |
| Zdroj: | The Journal of infectious diseases. 145(2) |
| ISSN: | 0022-1899 |
| Popis: | Ten cases of antibiotic-associated colitis (AAC) were identified at a hospital in Washington, D.C., from March 17 to May 9, 1979. No geographic clustering of cases was found, nor was an association with increased use of antibiotics demonstrated. Exposure to aminoglycosides, cephalosporins, and clindamycin was associated with AAC, as was a history of enemas in the seven days before the onset of illness (P=0.045). This association was strengthened when gastrointestinal procedures-defined as (1) three or more enemas per week, (2) the insertion of a nasogastric tube for two or more days, or (3) gastrointestinal surgery-were performed within seven days of the onset of illness (P=0.007). Clostridium difficile was not isolated from the hospital environments, nursing personnel, or family members of the patients. C. difficile was isolated from stool specimens of five (36%) of 14 patients who served as controls. |
| Databáze: | OpenAIRE |
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