An oligomeric hyaluronic acid-GX1 molecular target drug with polyvalent targeting to CD44 and VEGF receptors

Autor:	Pei, Jing, Yuling, Luo, Liang, Wang, Jiangbing, Tan, Yun, Chen, Ying, Chen, Shiyong, Zhang
Rok vydání:	2023
Předmět:	Vascular Endothelial Growth Factor A Biomaterials Mice Drug Delivery Systems Receptors Vascular Endothelial Growth Factor Biomedical Engineering Animals Antineoplastic Agents Bioengineering Hyaluronic Acid
Zdroj:	Biomaterials Advances. 144:213217
ISSN:	2772-9508
DOI:	10.1016/j.bioadv.2022.213217
Popis:	The off-target toxicity of molecular targeted drug hinders its clinical transformation. Herein, we report a new molecular targeted drug oHA-GX1 constructed by oligomeric hyaluronan (oHA) and peptide GX1 (CGNSNPKSC). The oHA-GX1 can not only suppress the tumor growth by interacting with overexpressed VEGF and CD44 receptors inside tumor tissues, but also reduce the likelihood of off-target toxicity due to the multiple VEGF and CD44 receptors binding sites. The cytotoxicity study shows that the IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a71c5b3ab3e58cc7e75246fad3e6109 https://doi.org/10.1016/j.bioadv.2022.213217 Zobrazit plný text záznamu Full Text from ScienceDirect