Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors
| Autor: | Yipeng Cao, Wei Wang, Xiangfei Meng, Imshik Lee, Wenwen Zhang, Rui Yang, Jiana Sun |
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| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular Antagonists & inhibitors Protein Conformation viruses coronavirus Virulence Reviews Sequence alignment Computational biology Review Biology medicine.disease_cause Biochemistry Antiviral Agents Viroporin Proteins 03 medical and health sciences Coronavirus Envelope Proteins Protein structure Protein sequencing Viral life cycle COVID‐19 inhibitors medicine Animals Humans Amino Acid Sequence skin and connective tissue diseases Molecular Biology Peptide sequence 030304 developmental biology Coronavirus E protein 0303 health sciences SARS-CoV-2 030302 biochemistry & molecular biology fungi virus diseases COVID-19 respiratory tract diseases COVID-19 Drug Treatment viroporin Corrigendum Sequence Alignment |
| Zdroj: | Protein Sci Protein Science : A Publication of the Protein Society |
| ISSN: | 1469-896X |
| Popis: | The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The SARS‐CoV‐2 envelope (E) protein is a small structural protein involved in many aspects of the viral life cycle. The E protein promotes the packaging and reproduction of the virus, and deletion of this protein weakens or even abolishes the virulence. This review aims to establish new knowledge by combining recent advances in the study of the SARS‐CoV‐2 E protein and by comparing it with the SARS‐CoV E protein. The E protein amino acid sequence, structure, self‐assembly characteristics, viroporin mechanisms and inhibitors are summarized and analyzed herein. Although the mechanisms of the SARS‐CoV‐2 and SARS‐CoV E proteins are similar in many respects, specific studies on the SARS‐CoV‐2 E protein, for both monomers and oligomers, are still lacking. A comprehensive understanding of this protein should prompt further studies on the design and characterization of effective targeted therapeutic measures. |
| Databáze: | OpenAIRE |
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