Cerebrospinal fluid analyses for the diagnosis of subarachnoid haemorrhage and experience from a Swedish study. What method is preferable when diagnosing a subarachnoid haemorrhage?
| Autor: | Markus Otto, Karin Nagy, Axel Petzold, Manfred Uhr, Hayrettin Tumani, Henrik Zetterberg, Axel Regeniter, Jörg Kraus, Ina Skagervik, Manfred Wick, Johannes Brettschneider, Kaj Blennow, Niklas Mattsson, Ronald Lautner, Leslie M. Shaw, Florian Deisenhammer, H. Kuhn |
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| Přispěvatelé: | Neurology, NCA - neurodegeneration |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Computed tomography Clinical Chemistry Tests Cerebrospinal fluid Xanthochromia Case fatality rate Medicine Humans cardiovascular diseases Sweden medicine.diagnostic_test business.industry Mortality rate Biochemistry (medical) General Medicine Subarachnoid Hemorrhage medicine.disease Surgery Ferritin measurement Spectrophotometry Erythrocyte Count Subarachnoid haemorrhage Radiology business Positive Finding |
| Zdroj: | Nagy, K, Skagervik, I, Tumani, H, Petzold, A, Wick, M, Kuhn, H J, Uhr, M, Regeniter, A, Brettschneider, J, Otto, M, Kraus, J, Deisenhammer, F, Lautner, R, Blennow, K, Shaw, L, Zetterberg, H & Mattsson, N 2013, ' Cerebrospinal fluid analyses for the diagnosis of subarachnoid haemorrhage and experience from a Swedish study. What method is preferable when diagnosing a subarachnoid haemorrhage? ', Clinical Chemistry and Laboratory Medicine, vol. 51, no. 11, pp. 2073-2086 . https://doi.org/10.1515/cclm-2012-0783 Clinical Chemistry and Laboratory Medicine, 51(11), 2073-2086. Walter de Gruyter GmbH |
| ISSN: | 1434-6621 |
| Popis: | Subarachnoid haemorrhage (SAH) has a high mortality and morbidity rate. Early SAH diagnosis allows the early treatment of a ruptured cerebral aneurysm, which improves the prognosis. Diagnostic cerebrospinal fluid (CSF) analyses may be performed after a negative computed tomography scan, but the precise analytical methods to be used have been debated. Here, we summarize the scientific evidence for different CSF methods for SAH diagnosis and describe their implementation in different countries. The principle literature search was conducted using PubMed and Scopus with the search items “cerebrospinal fluid”, “subarachnoid haemorrhage”, and “diagnosis”. CSF analyses for SAH include visual examination, red blood cell counts, spectrophotometry for oxyhaemoglobin or bilirubin determination, CSF cytology, and ferritin measurement. The methods vary in availability and performance. There is a consensus that spectrophotometry has the highest diagnostic performance, but both oxyhaemoglobin and bilirubin determinations are susceptible to important confounding factors. Visual inspection of CSF for xanthochromia is still frequently used for diagnosis of SAH, but it is advised against because spectrophotometry has a superior diagnostic accuracy. A positive finding of CSF bilirubin is a strong indicator of an intracranial bleeding, whereas a positive finding of CSF oxyhaemoglobin may indicate an intracranial bleeding or a traumatic tap. Where spectrophotometry is not available, the combination of CSF cytology for erythrophages or siderophages and ferritin is a promising alternative. |
| Databáze: | OpenAIRE |
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