Experimental Models for Prevention of Graft-versus-Host Reaction in Bone Marrow Transfusion
| Autor: | Nagahide Goya, Ataru Kuroiwa, Kikuo Nomoto, Kenji Takeya, Sumio Miyazaki |
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| Rok vydání: | 1976 |
| Předmět: |
Graft versus host reaction
Bone Marrow Cells Spleen Graft vs Host Reaction Mice Mice Inbred AKR medicine Animals Transplantation Homologous Cytotoxic T cell Cytotoxicity Bone Marrow Transplantation business.industry General Medicine Cytotoxicity Tests Immunologic Molecular biology Complete adjuvant Mice Inbred C57BL medicine.anatomical_structure Splenomegaly Immunology Bone marrow transfusion Cellular antigens Bone marrow business |
| Zdroj: | Japanese Journal of Microbiology. 20:493-498 |
| ISSN: | 0021-5139 |
| DOI: | 10.1111/j.1348-0421.1976.tb01017.x |
| Popis: | Induction and suppression of splenomegaly and cytotoxicity against C57BL/L cells were studied in (AKR X C57BL/6) F1 hybrid adult mice after the transfer of AKR lymphoid and bone marrow cells. 1) Splenomegaly and cytotoxicity were dissociated in the developmental stages of the graft-versus-host reaction. When lymphoid and bone marrow cells of normal AKR mice were injected into F1 recipients, splenomegaly was prominent on days 5 and 7, but cytotoxicity of spleen cells was not detected. Splenomegaly became less prominent but the cytotoxicity became detectable on day 14 after the injection. 2) Cytotoxic activity of spleen cells of F1 recipients was suppressed by the treatment of AKR donors with C57BL/6 lymphoid cells in Freund's complete adjuvant. Splenomegaly, however, was substantially enhanced by such a treatment of the donors. On the other hand, induction of the cytotoxic activity was facilitated by the treatment of donors with C57BL/6 skin grafts. 3) F1 hybrid mice could be protected from the graft-versus-host reaction by the injection of AKR anti-C57BL/6 serum or pretreatment of AKR donors with sonicated cellular antigens of C57BL/6. |
| Databáze: | OpenAIRE |
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