Bleeding patterns with the levonorgestrel-releasing intrauterine system when used for heavy menstrual bleeding in women without structural pelvic pathology: a pooled analysis of randomized controlled studies
Autor: | Diana Mansour, Jeffrey T. Jensen, Ian S. Fraser, Karin Burock, Pirjo Inki, Eeva Lukkari-Lax |
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Rok vydání: | 2012 |
Předmět: |
Adult
medicine.medical_specialty Pathology Time Factors media_common.quotation_subject Levonorgestrel law.invention Menstruation Randomized controlled trial law medicine Contraceptive Agents Female Humans Amenorrhea Menorrhagia Menstrual cycle media_common Obstetrics business.industry Intrauterine Devices Medicated Obstetrics and Gynecology Menstrual bleeding Pooled analysis Reproductive Medicine Family planning Female medicine.symptom business medicine.drug |
Zdroj: | Contraception. 87(1) |
ISSN: | 1879-0518 |
Popis: | Background The study was conducted to characterize the changes in bleeding pattern over time in women receiving the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding (HMB). The reduction in menstrual blood loss volume has been well documented elsewhere. Study Design Post hoc pooled analysis of the impact of the LNG-IUS on bleeding patterns in four comparator studies of medical and surgical treatment options for HMB. We enrolled women aged ≥ 18 years with HMB without organic pathology. The change in the number of bleeding and spotting (B/S) days and bleeding patterns was assessed over the duration of the studies pooled. Results One hundred and sixty-three women received the LNG-IUS in randomized trials. Relative to pretreatment baseline, there was a transient increase in the mean number of bleeding days in the first month of treatment, which returned to baseline by the second month and declined thereafter. Although the number of spotting days also increased during the first month of treatment, these declined with continued use but remained elevated relative to baseline during the first year of treatment. Conclusion In women with HMB, the LNG-IUS is associated with an initial increase in number of B/S days that improve over time. |
Databáze: | OpenAIRE |
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