Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials
| Autor: | Xiangli Yang, Chunwei Yang, Shengli Wei, Fei Wu, Lin Wang, Lin Niu, Fucun Song, Jixiang Liu, Yang Yang, Yizhuo Xing |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Nasopharyngeal neoplasm metronidazole amino acidum natrium Antineoplastic Agents Gastroenterology lcsh:RC254-282 law.invention Randomized controlled trial law Internal medicine Metronidazole medicine Odds Ratio Combined Modality Therapy Humans Radiology Nuclear Medicine and imaging Randomized Controlled Trials as Topic Nasopharyngeal Carcinoma business.industry Carcinoma Nasopharyngeal Neoplasms General Medicine Publication bias medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Surgery Radiation therapy radiation Meta-analysis Treatment Outcome Oncology Nasopharyngeal carcinoma business Publication Bias medicine.drug |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 11, Iss 6, Pp 222-225 (2015) |
| ISSN: | 1998-4138 |
| Popis: | Objective: We performed this meta-analysis to assess the metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma. Materials and Methods: Two reviewers independently reviewed the databases of PubMed and CNKI. The prospective, randomized, controlled trials of metronidazole amino acidum natrium combined with radiation versus radiotherapy alone in the treatment of nasopharyngeal carcinoma were included in this meta-analysis. The objective response rate (RR) of 1-, 3-, and 5-year survival rates were pooled by statistical software. The publication bias was evaluated by Begg's funnel plot. Results: Sixteen prospective, randomized, controlled trials were finally included in this meta-analysis. The quality assessment showed that the method's quality was relatively poor. The pooled results showed that the metronidazole amino acidum natrium combined with radiation can significantly improve the objective RR for the primary lesion (RR = 1.37, 95% confidence interval [CI]: 1.23–1.53, P < 0.05) and neck metastasis lesion (RR = 1.36, 95% CI: 1.25–1.49, P < 0.05). For survival analysis, the combined treatment can significantly improve the 1-year survival (RR = 1.57, 95% CI: 1.28–1.93, P < 0.05), 3-year survival (RR = 1.23, 95% CI: 1.06–1.41, P < 0.05), and 5-year survival rates (RR = 1.27, 95% CI: 1.05–1.53, P < 0.05). Conclusion: Metronidazole amino acidum natrium combined with radiation can improve the objective RR and long-term survival compared to radiation therapy alone in the treatment of nasopharyngeal carcinoma. |
| Databáze: | OpenAIRE |
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