Comparison of the prognostic value of ECOG-PS, mGPS and BMI/WL: Implications for a clinically important framework in the assessment and treatment of advanced cancer
| Autor: | Wei M. J. Sim, Aoife M. Ryan, Barry Laird, Ross D. Dolan, Donald C. McMillan, Marie Fallon, Louise E. Daly |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Weakness 030209 endocrinology & metabolism Anorexia Critical Care and Intensive Care Medicine Body Mass Index Prognostic score Cohort Studies 03 medical and health sciences 0302 clinical medicine Weight loss Neoplasms Internal medicine Weight Loss medicine Humans In patient Prospective Studies Aged Aged 80 and over 030109 nutrition & dietetics Nutrition and Dietetics Proportional hazards model business.industry Middle Aged Physical Functional Performance Prognosis Advanced cancer United Kingdom Survival Rate Body Composition Female medicine.symptom business Ireland Body mass index |
| Zdroj: | Dolan, R D, Daly, L, Sim, W, Fallon, M, Ryan, A, McMillan, D & Laird, B 2019, ' Comparison of the prognostic value of ECOG-PS, MGPS and BMI/WL: Implications for a clinically important framework in the assessment and treatment of advanced cancer ', Clinical Nutrition . https://doi.org/10.1016/j.clnu.2019.12.024 |
| ISSN: | 0261-5614 |
| Popis: | The systemic inflammatory response is associated with the loss of lean tissue, anorexia, weakness, fatigue and reduced survival in patients with advanced cancer and therefore is important in the definition of cancer cachexia. The aim of the present study was to carry out a direct comparison of the prognostic value of Eastern Cooperative Oncology Group Performance Status (ECOG-PS), modified Glasgow Prognostic Score (mGPS) and Body Mass Index/Weight Loss Grade (BMI/WL grade) in patients with advanced cancer.All data were collected prospectively across 18 sites in the UK and Ireland. Patient's age, sex, ECOG-PS, mGPS and BMI/WL grade were recorded, as were details of underlying disease including metastases. Survival data were analysed using univariate and multivariate Cox regression.A total of 730 patients were assessed. The majority of patients were male (53%), over 65 years of age (56%), had an ECOG-PS0/1 (56%), mGPS≥1 (56%), BMI≥25 (51%),2.5% weight loss (57%) and had metastatic disease (86%). On multivariate cox regression analysis ECOG-PS (HR 1.61 95%CI 1.42-1.83, p 0.001), mGPS (HR 1.53, 95%CI 1.39-1.69, p 0.001) and BMI/WL grade (HR 1.41, 95%CI 1.25-1.60, p 0.001) remained independently associated with overall survival. In patients with a BMI/WL grade 0/1 both ECOG and mGPS remained independently associated with overall survival.The ECOG/mGPS framework may form the basis of risk stratification of survival in patients with advanced cancer. |
| Databáze: | OpenAIRE |
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