Antioxidative Effect of Kaempferol and Its Equimolar Mixture with Phenyltin Compounds on UV-Irradiated Liposome Membranes
| Autor: | Stanisław Przestalski, Monika Soczyńska-Kordala, Janina Gabrielska |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Liposome Antioxidant Triphenyltin chloride Ultraviolet Rays medicine.medical_treatment Flavonoid General Chemistry Antioxidants chemistry.chemical_compound Membrane chemistry Polyphenol Phosphatidylcholine Liposomes Organotin Compounds Phosphatidylcholines medicine Organic chemistry Drug Interactions Kaempferols General Agricultural and Biological Sciences Kaempferol Oxidation-Reduction Nuclear chemistry |
| Zdroj: | Journal of Agricultural and Food Chemistry. 53:76-83 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf0401120 |
| Popis: | The work investigates the possibility of the protective action of kaempferol on phosphatidylcholine liposome membranes exposed to the pro-oxidative action of diphenyltin dichloride (DPhT) and triphenyltin chloride (TPhT) induced by UV radiation (lambda = 253.7 nm). The concentrations of kaempferol and its equimolar mixtures with DPhT and TPhT were determined so that they induce 50% inhibition in oxidation of liposomes irradiated with UV. They are 11.6, 10.0, and 4.5 microM/L, which constitute the following sequence of antioxidative activity: kaempferol/triphenyltinkaempferol/diphenyltinkaempferol. This relationship is confirmed by the results on the antiradical ability of kaempferol and its mixtures with DPhT and TPhT toward the free radical 2,2-diphenyl-1-picrylhydrazyl. Similar sequences obtained in both studies suggest a possible mechanism of the antiradical action of the mixtures as free radical scavengers. Kaempferol's ability, then documented, to form complexes with phenyltins indicates (a) a possible way to liquidate the peroxidation caused by the free radical forms of phenyltins and (b) the stabilizing role of chelating in the antioxidative action of the kaempferol/phenyltins. The differentiation in the action of the compounds studied may, among others, result from different localizations in the liposome membrane, which is indicated by the results of the fluorometric studies. |
| Databáze: | OpenAIRE |
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