| Autor: |
Iryna Fomochkina, Denis V. Chegodar, Yuliana I. Shramko, Anatoliy V. Kubyshkin, Inna V. Chernousova, Yury A. Ogai, Leonid L. Aliev |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Russian Open Medical Journal, Vol 7, Iss 4, p e0405 (2018) |
| ISSN: |
2304-3415 |
| Popis: |
Objective — Biological effects of grape processing products (GPP) rich in polyphenols are still not studied completely. The aim of the investigation was to study co-interactions between peroxidation lipid oxidation (PLO) and nonspecific proteases and their inhibitors activity in the animals with the model of metabolic syndrome (MS) corrected with GPP. Material and Methods — The study was performed on 54 white male rats of the weight of 180-200 g. The animals of experimental groups were fed by the standard menu and were given 10% fructose solution instead the drinking water during 8 weeks, which promoted development of MS. “Enoant”, “Enoant-premium” and “Fenocor” were used as GPP in dosage of 2.5 ml/kg during 4 weeks just after 5th week. The PLO was estimated according to the concentration of thiobarbituric acid active products (TBA-AP), ceruloplasmin (CC), catalase-like activity (CLA), peroxidase-like activity (PLA) and superoxide dismutase activity (SOD). Trypsin-like activity (TLA), elastase-like activity (ELA), alfa-1-antitripsin activity (ATA) and acid-stable inhibitors activity (ASA) were estimated. Results —MS demonstrated rise of TBA-AP by 50.4 % (р |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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