Maternal Obesity, Gestational Weight Gain, and Offspring Adiposity: The Exploring Perinatal Outcomes among Children Study
| Autor: | Tessa L. Crume, Jill L. Kaar, Robert S. McDuffie, Dana Dabelea, Kimberly Bischoff, John T. Brinton |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Offspring Subcutaneous Fat Overweight Weight Gain Article Childhood obesity Body Mass Index Pregnancy Internal medicine medicine Humans Obesity Prospective Studies Child Obstetrics business.industry Cholesterol HDL Pregnancy Outcome medicine.disease Pregnancy Complications Endocrinology Pediatrics Perinatology and Child Health Homeostatic model assessment Female Waist Circumference medicine.symptom business Body mass index Weight gain |
| Zdroj: | The Journal of Pediatrics. 165:509-515 |
| ISSN: | 0022-3476 |
| Popis: | To determine whether adequate vs excessive gestational weight gain (GWG) attenuated the association between maternal obesity and offspring outcomes.Data from 313 mother-child pairs participating in the Exploring Perinatal Outcomes among Children study were used to test this hypothesis. Maternal prepregnancy body mass index (BMI) and weight measures throughout pregnancy were abstracted from electronic medical records. GWG was categorized according to the 2009 Institute of Medicine criteria as adequate or excessive. Offspring outcomes were obtained at a research visit (average age 10.4 years) and included BMI, waist circumference (WC), subcutaneous adipose tissue (SAT) and visceral adipose tissue, high-density lipoprotein cholesterol, and triglyceride levels.More overweight/obese mothers exceeded the Institute of Medicine GWG recommendations (68%) compared with normal-weight women (50%) (P.01). Maternal prepregnancy BMI was associated with worse childhood outcomes, particularly among offspring of mothers with excessive GWG (increased BMI [20.34 vs 17.80 kg/m(2)], WC [69.23 vs 62.83 cm], SAT [149.30 vs 90.47 cm(2)], visceral adipose tissue [24.11 vs 17.55 cm(2)], and homeostatic model assessment [52.52 vs 36.69], all P.001). The effect of maternal prepregnancy BMI on several childhood outcomes was attenuated for offspring of mothers with adequate vs excessive GWG (P.05 for the interaction between maternal BMI and GWG status on childhood BMI, WC, SAT, and high-density lipoprotein cholesterol).Our findings lend support for pregnancy interventions aiming at controlling GWG to prevent childhood obesity. |
| Databáze: | OpenAIRE |
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