Prenatal smoking exposure and neonatal DNA damage in relation to birth outcomes
| Autor: | Hsien-Tsai Chiu, Tsan Hung Chiu, Ruey-Yun Wang, Chouh-Jiuan Lin, Huai-Chih Tsui, Hong Dar Isaac Wu, Yang-Chen Cheng, Fang-Yang Wu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Passive smoking Birth weight Taiwan Prenatal care medicine.disease_cause Tobacco smoke Pregnancy Risk Factors medicine Humans Fetus Obstetrics business.industry Smoking Infant Newborn Pregnancy Outcome Gestational age medicine.disease Health Surveys Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Gestation Regression Analysis Female Comet Assay business DNA Damage |
| Zdroj: | Pediatric research. 64(2) |
| ISSN: | 0031-3998 |
| Popis: | This study investigated whether mothers with prenatal environmental tobacco smoke (ETS) exposure increased the newborn genetic damage and adverse birth outcomes. Study participants were women receiving prenatal care at three hospitals in Central Taiwan and their newborns. Participants were divided into two groups (nonsmokers and ETS-exposed non-smokers) based on maternal ETS-exposed status. Comet assay were performed for cord blood samples. Infants born to mothers with prenatal ETS exposure had the highest mean cord blood DNA damage score (69.7 +/- 42.3) and poorer birth outcomes. No negative fetal growth effects appeared among newborns with low DNA damage levels. Among newborns with high DNA damage levels (comet scores >50), those born to prenatal ETS exposure had an average reduction of 252.7 g in birth weight, 1.10 cm shorter in length and a 0.92-cm decrease in head circumference, compared to newborns with no smoking exposure. This study shows that the DNA damage scores can be used as an effect-modifier on the relationships between ETS exposure and adverse birth outcome. The association appears more apparent for the ETS exposure in relation with more severe DNA damage. |
| Databáze: | OpenAIRE |
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