Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules
| Autor: | Yanrong Zhang, Thomas D. Legalley, Wei Bi, K. Michael Gibson, Catherine E. Bammert, Xin Yan, Ping Xue, Jia Xiang Wang, Yue Bi, Lanrong Bi, Xiang Gao |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nitroxide mediated radical polymerization Antioxidant medicine.drug_class medicine.medical_treatment Clinical Biochemistry Ischemia Pharmaceutical Science Pain Pharmacology Mitochondrion Xylenes Biochemistry Anti-inflammatory Kyotorphin Antioxidants Toxicology 03 medical and health sciences chemistry.chemical_compound Mice Structure-Activity Relationship Drug Discovery medicine Animals Edema Molecular Biology Pain Measurement Analgesics Dose-Response Relationship Drug Molecular Structure Chemistry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal medicine.disease 3. Good health Mitochondria 030104 developmental biology Molecular Medicine Nitrogen Oxides Endorphins Cellular model Function (biology) |
| Zdroj: | Bioorganicmedicinal chemistry letters. 26(8) |
| ISSN: | 1464-3405 |
| Popis: | Mitochondrial oxidative damage contributes to a wide range of pathologies, including ischemia/reperfusion (I/R) injury, cardiovascular disorders and neurodegenerative diseases. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel kyotorphin-nitroxide hybrid molecules, and examined their free radical scavenging activities, in addition to their anti-inflammatory and analgesic activities. We have further characterized these compounds in a simulated I/R cellular model. Our findings suggest that the protective effects of kyotorphin-nitroxides partially reside in maintaining optimal mitochondrial function. |
| Databáze: | OpenAIRE |
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