Addition of a dairy fraction rich in milk fat globule membrane to a high-saturated fat meal reduces the postprandial insulinaemic and inflammatory response in overweight and obese adults
| Autor: | Elieke Demmer, Angela M. Zivkovic, Nancy Rivera, Erik R. Gertz, Jennifer T. Smilowitz, J. Bruce German, Marta D. Van Loan, Tara S. Rogers |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Postprandial inflammation: Saturated fat: Insulin: C-reactive protein: CVD: Cytokines [Milk fat globule membrane] Endocrinology Diabetes and Metabolism Saturated fat medicine.medical_treatment 030204 cardiovascular system & hematology Overweight PO chemistry.chemical_compound 0302 clinical medicine soluble intracellular adhesion molecule MetS Insulin Meal palm oil Nutrition and Dietetics CVD Postprandial sICAM CRP C-reactive protein Cytokines MetS metabolic syndrome medicine.symptom CRP incremental AUC MFGM Research Article sICAM soluble intracellular adhesion molecule medicine.medical_specialty Clinical Trials and Supportive Activities Biology iAUC metabolic syndrome C-reactive protein 03 medical and health sciences PO palm oil Insulin resistance Clinical Research Internal medicine Milk fat globule membrane medicine Obesity Metabolic and endocrine Nutrition 030109 nutrition & dietetics Cholesterol MFGM milk fat globule membrane Postprandial inflammation medicine.disease Atherosclerosis iAUC incremental AUC Endocrinology chemistry Metabolic syndrome Food Science |
| Zdroj: | Journal of Nutritional Science |
| Popis: | Meals high in SFA, particularly palmitate, are associated with postprandial inflammation and insulin resistance. Milk fat globule membrane (MFGM) has anti-inflammatory properties that may attenuate the negative effects of SFA-rich meals. Our objective was to examine the postprandial metabolic and inflammatory response to a high-fat meal composed of palm oil (PO) compared with PO with an added dairy fraction rich in MFGM (PO+MFGM) in overweight and obese men and women (n 36) in a randomised, double-blinded, cross-over trial. Participants consumed two isoenergetic high-fat meals composed of a smoothie enriched with PO with v. without a cream-derived complex milk lipid fraction ( dairy fraction rich in MFGM) separated by a washout of 1–2 weeks. Serum cytokines, adhesion molecules, cortisol and markers of inflammation were measured at fasting, and at 1, 3 and 6 h postprandially. Glucose, insulin and lipid profiles were analysed in plasma. Consumption of the PO + MFGM v. PO meal resulted in lower total cholesterol (P = 0·021), LDL-cholesterol (P = 0·046), soluble intracellular adhesion molecule (P = 0·005) and insulin (P = 0·005) incremental AUC, and increased IL-10 (P = 0·013). Individuals with high baseline C-reactive protein (CRP) concentrations (≥3 mg/l, n 17) had higher (P = 0·030) insulin at 1 h after the PO meal than individuals with CRP concentrations n 19). The addition of MFGM attenuated this difference between CRP groups. The addition of a dairy fraction rich in MFGM attenuated the negative effects of a high-SFA meal by reducing postprandial cholesterol, inflammatory markers and insulin response in overweight and obese individuals, particularly in those with elevated CRP. |
| Databáze: | OpenAIRE |
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