Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole
| Autor: | Kennan C. Marsh, Yu-hua Hui, Jacob J. Clement, Michael J. Mitten, Lisa E. Hernandez, Nate Shipkowitz, Jeffrey Alder |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Microbiology (medical) Sulfamethoxazole medicine.drug_class medicine.medical_treatment Antibiotics Biology Dexamethasone Rats Sprague-Dawley Pharmacokinetics Clarithromycin Trimethoprim Sulfamethoxazole Drug Combination parasitic diseases medicine Animals Humans Pharmacology (medical) Cyst Pentamidine Immunosuppression Therapy Pharmacology Chemotherapy Pneumonia Pneumocystis bacterial infections and mycoses medicine.disease Rats respiratory tract diseases Infectious Diseases Pneumocystis carinii Immunology Drug Therapy Combination medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 33:253-263 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/33.2.253 |
| Popis: | The efficacy of clarithomycin and sulphamethoxazole for treatment of experimental Pneumocystis carinii infection was investigated. Rats were immunosuppressed with dexamethasone and inoculated intratracheally with 5 x 10(6) P. carinii cysts. After 2 weeks, the lung tissues were assayed for P. carinii cyst burden. The combination of clarithromycin and sulphamethoxazole caused a significantly greater reduction in cyst burden than either drug alone. Up to 50% of the rats treated with the combination of clarithromycin and sulphamethoxazole were negative for P. carinii cysts. Equivalent doses of the individual drugs given alone did not produce cures. The combination of clarithromycin and sulphamethoxazole was more than twice as effective as either drug alone. Clarithromycin combined with sulphamethoxazole in treatment of P. carinii infection could be especially useful since clarithromycin monotherapy provides safe and effective treatment against many other pathogens, including several that are associated with AIDS. |
| Databáze: | OpenAIRE |
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