L-glutamate increases the spontaneous release of [3H]GABA from cultured cerebellar neurons
| Autor: | Gary R. Dutton, Brian R. Pearce |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cerebellum
Aspartic Acid Sodium Glutamate receptor Glutamic Acid Stereoisomerism Glutamic acid Biology Neuronal depolarization Stimulation Chemical Rats Cerebellar Cortex medicine.anatomical_structure nervous system Developmental Neuroscience Glutamates L glutamate medicine Biophysics Animals Calcium Neuroscience Cells Cultured gamma-Aminobutyric Acid Developmental Biology |
| Zdroj: | Brain research. 255(3) |
| ISSN: | 0006-8993 |
| Popis: | The effects of l-glutamate on the spontaneous release of [3H]GABA from cerebellar neurons in well characterized cerebellar monolayer cultures were investigated. The release process was dependent on Ca2+, elicited by neuronal depolarization and specific to l-glutamate. d-Glutamate and l-aspartate were without effect, and glutamic acid diethylester (GDEE) abolished l-glutamate stimulated 3H]GABA release, suggesting that this effect was mediated by glutamate receptors. |
| Databáze: | OpenAIRE |
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