Pyriproxyfen-treated bed nets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions

Autor: Wamdaogo M. Guelbeogo, James Maas, Rosemary Susan Lees, Sagnon N’Fale, Steven W. Lindsay, John C. Morgan, Hilary Ranson, Philip J. McCall, Nelson Grisales, Dimitri Wendgida Wangrawa
Rok vydání: 2021
Předmět:
Insecticides
Mosquito Control
Pyridines
Anopheles gambiae
RC955-962
Infectious and parasitic diseases
RC109-216
Insecticide Resistance
Toxicology
chemistry.chemical_compound
0302 clinical medicine
Arctic medicine. Tropical medicine
Pyrethrins
media_common
0303 health sciences
qx_4
Pyrethroid
Reproduction
Longevity
Fecundity
Olyset Duo®
3. Good health
Infectious Diseases
Juvenile hormone (JH)
Female
qx_515
medicine.drug
media_common.quotation_subject
030231 tropical medicine
Fertility
Biology
03 medical and health sciences
Anopheles
Burkina Faso
Insect growth regulator
parasitic diseases
medicine
Animals
Insecticide-treated nets (ITNs)
Insecticide-Treated Bednets
030304 developmental biology
Research
wa_240
Pyriproxyfen (PPF)
biology.organism_classification
chemistry
Pyrethroid-resistance
Parasitology
Genetic Fitness
Pyriproxyfen
Permethrin
Zdroj: Malaria journal, 2021, Vol.20(1), pp.273 [Peer Reviewed Journal]
Malaria Journal, Vol 20, Iss 1, Pp 1-17 (2021)
Malaria Journal
ISSN: 1475-2875
Popis: Background The efficacy of insecticide-treated nets (ITNs) containing the insect growth regulator pyriproxyfen (PPF) and pyrethroid insecticides (PPF-ITNs) is being assessed in clinical trials to determine whether they provide greater protection from malaria than standard pyrethroid-treated ITNs in areas where mosquitoes are resistant to pyrethroids. Understanding the entomological mode of action of this new ITN class will aide interpretation of the results from these trials. Methods Anopheles gambiae sensu lato (s.l.) mosquitoes from a susceptible laboratory strain were exposed to PPF-treated netting 24 h, 6 h, and immediately prior to, or 24 h post blood feeding, and the impact on fecundity, fertility and longevity recorded. Pyrethroid-resistant populations were exposed to nets containing permethrin and PPF (PPF-ITNs) in cone bioassays and daily mortality recorded. Mosquitoes were also collected from inside houses pre- and post-distribution of PPF-ITNs in a clinical trial conduced in Burkina Faso; female An. gambiae s.l. were then assessed for fecundity and fertility. Results PPF exposure reduced the median adult lifespan of insecticide-susceptible mosquitoes by 4 to 5 days in all exposure times (p An. gambiae s.l. females were collected from five villages between 1 and 12 months before distribution of PPF-ITNs. Of these mosquitoes, 75% laid eggs and the remaining 25% appeared to have normal ovaries upon dissection. In contrast, only 8.6% of the 631 blood-fed or gravid An. gambiae s.l. collected post PPF-ITN distribution successfully oviposited; 276 (43.7%) did not oviposit but had apparently normal ovaries upon dissection, and 301 (47.7%) did not oviposit and had abnormal eggs upon dissection. Egg numbers were also significantly lower (average of 138/female prior distribution vs 85 post distribution, p Conclusion Exposure to a mixture of PPF and pyrethroids on netting shortens the lifespan of mosquitoes and reduces reproductive output. Sterilization of vectors lasted at least one year under operational conditions. These findings suggest a longer effective lifespan of PPF-pyrethroid nets than reported previously.
Databáze: OpenAIRE
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