Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods
| Autor: | Lyrelle S. Lloyd, Steven R. Coombes, Richard J. Lewis, Ryan E. Mewis, Christopher J. Sleigh, Ralph W. Adams, Gary G. R. Green, Michael A. Bernstein, Simon B. Duckett |
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| Rok vydání: | 2012 |
| Předmět: |
Carbon Isotopes
Analyte Magnetic Resonance Spectroscopy Quinoline Analytical chemistry General Chemistry Nuclear magnetic resonance spectroscopy Spin isomers of hydrogen Biochemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry chemistry Quinolines Sample preparation Hyperpolarization (physics) Spectroscopy Two-dimensional nuclear magnetic resonance spectroscopy Hydrogen |
| Zdroj: | Journal of the American Chemical Society. 134:12904-12907 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja3051052 |
| Popis: | The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is being used to address the sensitivity limitation. Here, by reference to quinoline, we illustrate that the SABRE hyperpolarization technique, which uses para-hydrogen as the source of polarization, enables the rapid completion of a range of NMR measurements. These include the collection of (13)C, (13)C{(1)H}, and NOE data in addition to more complex 2D COSY, ultrafast 2D COSY and 2D HMBC spectra. The observations are made possible by the use of a flow probe and external sample preparation cell to re-hyperpolarize the substrate between transients, allowing repeat measurements to be made within seconds. The potential benefit of the combination of SABRE and 2D NMR methods for rapid characterization of low-concentration analytes is therefore established. |
| Databáze: | OpenAIRE |
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