Effect of pulmonary rehabilitation programs including lower limb endurance training on dyspnea in stable COPD: A systematic review and meta-analysis
| Autor: | Yuji Tohda, Yusaku Nishikawa, Kanji Fukuda, Akiko Sano, Sho Saeki, Morihide Ando, Yuji Higashimoto |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.medical_treatment Walk Test law.invention 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Quality of life Randomized controlled trial law Endurance training Surveys and Questionnaires Medicine Humans Pulmonary rehabilitation 030212 general & internal medicine Adverse effect Lung COPD Rehabilitation Exercise Tolerance business.industry medicine.disease Endurance Training Dyspnea Treatment Outcome 030228 respiratory system Lower Extremity Meta-analysis Physical therapy business |
| Zdroj: | Respiratory investigation. 58(5) |
| ISSN: | 2212-5353 |
| Popis: | Pulmonary rehabilitation (PR) is recommended as an effective treatment for patients with chronic obstructive pulmonary disease (COPD). Previous meta-analyses showed that PR improves exercise capacity and health-related quality of life (HRQOL). However, they did not evaluate the effect of PR on the sensation of dyspnea. We searched six databases in May 2019 for randomized controlled trials (RCTs) that examined PR, including supervised lower limb endurance training as a minimal essential component that was continued for 4–12 weeks, in patients with stable COPD, with changes from baseline dyspnea as a primary outcome. Secondary outcomes were changes in exercise capacity, HRQOL, activity of daily life (ADL), physical activity (PA), and adverse events. We calculated the pooled weighted mean difference (MD) using a random effects model. We identified 42 studies with 2150 participants. Compared with the control, PR improved dyspnea, as shown using the British Medical Research Council (MRC) questionnaire (MD, −0.64; 95% CI, −0.99 to −0.30; p = 0.0003), transitional dyspnea index (MD, 1.95; 95% CI, 1.09 to 2.81; p = 0.0001), modified Borg score during exercise (MD, −0.62; 95% CI, −1.10 to −0.14; p = 0.01), and Chronic Respiratory Questionnaire (CRQ) dyspnea score (MD, 0.91; 95% CI, 0.39 to 1.44; p = 0.0007). PR significantly increased exercise capacity measured by the 6 min walking distance time, peak workload, and peak VO2. It improved HRQOL measured by the St. George's Respiratory Questionnaire and CRQ, but not on PA or ADL. These results indicated that PR programs including lower limb endurance training improve dyspnea, HRQOL, and exercise capacity in patients with stable COPD. |
| Databáze: | OpenAIRE |
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