Association between seropositivity to Chlamydia pneumoniae and acute ischaemic stroke
| Autor: | J. Gil Madre, J. R. Garcia Escribano, J. Dominguez Martinez, J. Mendoza Montero, R. Fernandez Cenjor, J. L. Rodriguez Garcia, E. Botia Paniagua, R. Carranza Gonzalez |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Pathology Brain Ischemia Seroepidemiologic Studies Internal medicine Ischaemic stroke Medicine Humans Pooled data In patient Chlamydophila Infections Aged Aged 80 and over Chlamydia biology business.industry Chlamydophila pneumoniae Middle Aged Control subjects medicine.disease Antibodies Bacterial Stroke Chronic infection Neurology Acute Disease biology.protein Female Neurology (clinical) Antibody business |
| Zdroj: | European journal of neurology. 9(3) |
| ISSN: | 1351-5101 |
| Popis: | Recent studies suggest an association between Chlamydia pneumoniae infection with atherosclerosis, including cerebrovascular disease. We investigated the prevalence of Chlamydial seropositivity in patients with acute ischaemic stroke syndrome compared with age- and sex-matched control subjects. Specific antibodies (IgA) to C. pneumoniae were measured by microimmunofluorescence in both the clinical group (n=91) and the control group (n=112). Forty patients (43.9%) and 34 controls (30.3%) had positive IgA titres (P < 0.05). The pooled data from this and previous series yielded 45% of seropositivity in cerebrovascular patients vs. 19% in control subjects (P < 0.001). In conclusion, we suggest an association between chronic infection by C. pneumoniae and acute ischaemic stroke. |
| Databáze: | OpenAIRE |
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