Synthesis, thermal and spectroscopic behaviors of metal–drug complexes: La(III), Ce(III), Sm(III) and Y(III) amoxicillin trihydrate antibiotic drug complexes
| Autor: | Ragab R. Amin, Fathi M. Al-Azab, Yasmin M.S. Jamil, Hussein M.A. Al-Maydama, Moamen S. Refat |
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| Rok vydání: | 2014 |
| Předmět: |
Magnetic moment
Scanning electron microscope Chemistry Metal ions in aqueous solution Inorganic chemistry Amoxicillin Molar conductivity Fluorescence Atomic and Molecular Physics and Optics Anti-Bacterial Agents Analytical Chemistry Metal X-Ray Diffraction Metals visual_art visual_art.visual_art_medium Thermodynamics Thermal analysis Instrumentation Spectroscopy Powder diffraction Nuclear chemistry |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 128:427-446 |
| ISSN: | 1386-1425 |
| DOI: | 10.1016/j.saa.2014.02.160 |
| Popis: | The metal complexes of Amoxicillin trihydrate with La(III), Ce(III), Sm(III) and Y(III) are synthesized with 1:1 (metal:Amox) molar ratio. The suggested formula structures of the complexes are based on the results of the elemental analyses, molar conductivity, (infrared, UV-visible and fluorescence) spectra, effective magnetic moment in Bohr magnetons, as well as the thermal analysis (TG), and characterized by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The results obtained suggested that Amoxicillin reacted with metal ions as tridentate ligands, coordinating the metal ion through its amino, imino, and β-lactamic carbonyl. The kinetic thermodynamic parameters such as: Ea, ΔH(*), ΔS(*) and ΔG(*) were estimated from the DTG curves. |
| Databáze: | OpenAIRE |
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