Leukocyte adenosine triphosphatase activity in human bronchial asthma
| Autor: | Makoto Takahashi, Shigeki Shibahapa, Suetsugu Mue, Tamotsu Takishima, Tadao Ise |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1976 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent ATPase General Biochemistry Genetics and Molecular Biology Leukocyte Count Adenosine Triphosphate Internal medicine Cyclic AMP Leukocytes medicine Humans Atpase activity Asthmatic patient Magnesium Child Asthma Adenosine Triphosphatases Adenosine triphosphatase biology Chemistry General Medicine Middle Aged Control subjects medicine.disease Peripheral blood Endocrinology biology.protein Calcium Membrane fraction Adenylyl Cyclases |
| Zdroj: | Tohoku Journal of Experimental Medicine. 119(3):257-264 |
| ISSN: | 0040-8727 |
| Popis: | Changes in adenosine triphosphatase (ATPase) activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Estimation of the leukocyte Mg++. and Ca++. dependent ATPases was carried out according to Hadden's method, incubating ATP with the membrane fraction of the leukocyte. The leukocyte ATPase activity was signifi-cantly elevated among asthmatic patients compared with control subjects. This elevated ATPase was seen in all asthmatics irrespective of acute attacks or the drug treatment. There was no clear correlation between the activity of ATPase and the percentage of leukocytes, neutrophils and eosinophils. There was no relationship between ATPase activity and adenyl cyclase activity of the same leukocytes from asthmatic patients. |
| Databáze: | OpenAIRE |
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