| Autor: |
Amy E. Margolis, Jacob W. Cohen, Bruce Ramphal, Lauren Thomas, Virginia Rauh, Julie Herbstman, David Pagliaccio |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Biological Psychiatry Global Open Science. 2:292-300 |
| ISSN: |
2667-1743 |
| Popis: |
Children from economically distressed families and neighborhoods are at risk for stress and pollution exposure and potential neurotoxic sequelae. We examine dimensions of early-life stress affecting hippocampal volumes, how prenatal exposure to air pollution might magnify these effects, and associations between hippocampal volumes and visuospatial reasoning.Fifty-three Hispanic/Latinx and/or Black children of ages 7 to 9 years were recruited from a longitudinal birth cohort for magnetic resonance imaging and cognitive assessment. Exposure to airborne polycyclic aromatic hydrocarbons was measured during the third trimester of pregnancy. Maternal report of psychosocial stress was collected at child age 5 and served as measures of early-life stress. Whole hippocampus and subfield volumes were extracted using FreeSurfer. Wechsler performance IQ measured visuospatial reasoning.Maternal perceived stress associated with smaller right hippocampal volume among their children (B = -0.57,Prenatal and early-life exposures to chemical and social stressors are likely compounding. Socioeconomic deprivation and disparities increase risk of these exposures that exert critical neurobiological effects. Developing deeper understandings of these complex interactions will facilitate more focused public health strategies to protect and foster the development of children at greatest risk of mental and physical effects associated with poverty. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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