HCV and tumors correlated with immune system: a case-control study in an area of hyperendemicity
Autor: | Vincenzo Mettivier, Mariarosaria De Marco, Ferdinando Frigeri, Anna Crispo, Mario Tamburini, Domenico Ronga, Gabriella Fabbrocini, Orlando Antonio Spada, Vincenzo Tridente, Maurizio Montella |
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Rok vydání: | 2001 |
Předmět: |
Adult
Male Cancer Research Adolescent Endemic Diseases Hepatitis C virus Hepacivirus Disease medicine.disease_cause Immune system Risk Factors hemic and lymphatic diseases Immunopathology medicine Humans Multiple myeloma Aged Aged 80 and over business.industry Lymphoma Non-Hodgkin Cancer Hematology Middle Aged medicine.disease Hepatitis C Lymphoma Italy Oncology Case-Control Studies Immunology Female Multiple Myeloma Liver cancer business |
Zdroj: | Leukemia Research. 25:775-781 |
ISSN: | 0145-2126 |
Popis: | Hepatitis C virus (HCV) is a RNA virus that cannot be integrated with the host genome; it can, however, exert its oncogenetic potential indirectly by contributing to the modulator effects of the host immune system, probably through a capacity to elude the immune system. We have carried out a case controlled study on tumors correlated with the immune system (multiple myeloma, non-Hodgkin lymphoma and Hodgkin disease) and HCV, in a high prevalence area. The relationship between each cancer and HCV infection was assessed by means of odds ratios (ORs) and corresponding 95% confidence intervals. Risks were greater for B-cell non-Hodgkin lymphoma (OR=3.7, 95%CI, 1.9–7.4, P =0.0001) and multiple myeloma (OR=4.5, 95%CI, 1.9–10.7, P =0.0004). Our study is particularly important for public health, since it shows that during the coming years in the South of Italy, because of the high prevalence of HCV, there are good reasons to expect not only an increase of liver cancer, but also an increased incidence of great number of tumors correlated with the immune system. |
Databáze: | OpenAIRE |
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