Hox Proteins in the Regulation of Muscle Development
| Autor: | Andrew J. Saurin, Corinne Maurel-Zaffran, Yacine Graba, Gabriela Poliacikova |
|---|---|
| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Multiple stages
Mesoderm animal structures muscle QH301-705.5 Ectoderm Review Cell and Developmental Biology 03 medical and health sciences 0302 clinical medicine biology.animal mesoderm medicine Biology (General) Hox gene Transcription factor 030304 developmental biology 0303 health sciences patterning biology Vertebrate [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis Cell Biology biology.organism_classification Hox Cell biology medicine.anatomical_structure embryonic structures neuromuscular Drosophila melanogaster 030217 neurology & neurosurgery Function (biology) Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, ⟨10.3389/fcell.2021.731996⟩ Frontiers in Cell and Developmental Biology, Vol 9 (2021) Frontiers in Cell and Developmental Biology, 2021, 9, ⟨10.3389/fcell.2021.731996⟩ |
| ISSN: | 2296-634X |
| DOI: | 10.3389/fcell.2021.731996⟩ |
| Popis: | Hox genes encode evolutionary conserved transcription factors that specify the anterior–posterior axis in all bilaterians. Being well known for their role in patterning ectoderm-derivatives, such as CNS and spinal cord, Hox protein function is also crucial in mesodermal patterning. While well described in the case of the vertebrate skeleton, much less is known about Hox functions in the development of different muscle types. In contrast to vertebrates however, studies in the fruit fly, Drosophila melanogaster, have provided precious insights into the requirement of Hox at multiple stages of the myogenic process. Here, we provide a comprehensive overview of Hox protein function in Drosophila and vertebrate muscle development, with a focus on the molecular mechanisms underlying target gene regulation in this process. Emphasizing a tight ectoderm/mesoderm cross talk for proper locomotion, we discuss shared principles between CNS and muscle lineage specification and the emerging role of Hox in neuromuscular circuit establishment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|