Estimation of bladder volume from afferent neural activity
| Autor: | Jean-Jacques Wyndaele, Tomonori Minagawa, Arnaldo Mendez, Mohamad Sawan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Urinary system
Models Neurological Urinary Bladder Biomedical Engineering Neural Conduction Sensation Stimulation urologic and male genital diseases Tonic (physiology) Rats Sprague-Dawley Internal Medicine medicine Animals Neurons Afferent Urinary Bladder Neurogenic Isovolumetric contraction Monitoring Physiologic Nerve Fibers Unmyelinated Urinary bladder business.industry General Neuroscience Rehabilitation Signal Processing Computer-Assisted Neurophysiology Electric Stimulation Rats Electrophysiology medicine.anatomical_structure Data Interpretation Statistical Bladder volume Female Human medicine Implant business Mechanoreceptors Algorithms Biomedical engineering |
| Zdroj: | IEEE transactions on neural systems and rehabilitation engineering |
| ISSN: | 1558-0210 1534-4320 |
| Popis: | Refractive urinary dysfunction in individuals suffering from neurogenic bladder syndrome can be treated with implanted neurostimulators that restore, to some degree, the control of the urinary bladder. A sensor capable of relaying feedback from bladder activity to the implanted neurostimulator is required to implement a closed-loop system to improve overall implant efficacy and minimize deleterious effects to neural tissue caused by continuous electrical stimulation. In this paper, we present a method that allows real-time estimation of bladder volume from the primary afferent activity of bladder mechanoreceptors. Our method was validated with data acquired from anesthetized rats in acute experiments. It was possible to qualitatively estimate three states of bladder fullness in 100% of trials when the recorded afferent activity exhibited a Spearman's correlation coefficient of 0.6 or better. Furthermore, we could quantitatively estimate bladder volume, and also its pressure, using timeframes of properly chosen duration. The mean volume estimation error was $5.8 pm 3.1hbox{%}$. Our results also demonstrate that it is possible to quantify both phasic and tonic bladder responses during slow filling and isovolumetric measurements, respectively. |
| Databáze: | OpenAIRE |
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