The association of rs703842 variants in CYP27B1 with multiple sclerosis susceptibility is influenced by the HLA-DRB1*15:01 allele in Slovaks
| Autor: | Dusan Dobrota, Juraj Javor, Jozef Michalik, Daniel Čierny, Peter Dubovan, Egon Kurča, Ján Lehotský, Mária Škereňová |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Slovakia Multiple Sclerosis Immunology Population Protective factor 03 medical and health sciences 0302 clinical medicine Genotype medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele education Gene HLA-DRB1 Alleles Genetic Association Studies 25-Hydroxyvitamin D3 1-alpha-Hydroxylase education.field_of_study business.industry Multiple sclerosis Genetic Variation Middle Aged medicine.disease 030104 developmental biology Carriage Neurology Female Neurology (clinical) business 030217 neurology & neurosurgery HLA-DRB1 Chains |
| Zdroj: | Journal of Neuroimmunology. 330:123-129 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2019.03.006 |
| Popis: | In this study, we analysed the association of rs703842 in CYP27B1 gene with multiple sclerosis (MS) risk and disability progression in a group of 496 MS patients and 521 controls. For the first time in Central European Slovak population, we found the rs703842 allele C to be protective factor against MS development (p = 1.09 × 10−5). Moreover, the risky genotypes TT and TC were showed to be associated with an increased MS risk, and this was aggravated by the homozygous carriage of the HLA-DRB1*15:01 allele (OR = 2.82 vs. 4.86, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect