Epstein–Barr virus effect on frequency of functionally distinct T cell subsets in children with infectious mononucleosis
| Autor: | Anna Kroten, Elzbieta Ołdak, Alina Lipska, Artur Sulik, Piotr Radziwon |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Herpesvirus 4 Human Adolescent Mononucleosis T cell Population CD4-CD8 Ratio chemical and pharmacologic phenomena Biology medicine.disease_cause Virus Immune system T-Lymphocyte Subsets medicine Humans Infectious Mononucleosis Child education Immunity Cellular education.field_of_study CD28 hemic and immune systems General Medicine medicine.disease Epstein–Barr virus medicine.anatomical_structure Host-Pathogen Interactions Immunology Female Poland CD8 |
| Zdroj: | Advances in Medical Sciences. 59:227-231 |
| ISSN: | 1896-1126 |
| DOI: | 10.1016/j.advms.2014.04.003 |
| Popis: | Purpose Epstein–Barr virus is a common human pathogen which infects the great majority of population worldwide. A striking proliferation of CD8 + T cells is an immune response to EBV invasion of B lymphocytes during infectious mononucleosis. The aim of the study was to analyze frequencies of CD28 + CD95 − , CD28 + CD95 + , CD28 − CD95 + T cell subsets putative naive ( T N ), central ( T CM ) and effector memory ( T EM ) T cells in children with infectious mononucleosis. Material/methods Multiparameter flow cytometric analysis of CD4 + and CD8 + T cell subsets was performed in 19 children with acute infectious mononucleosis. Results The CD4 + /CD8 + ratio was found to be decreased (0.53) in children with infectious mononucleosis. Median T N , T CM , T EM frequencies were estimated to be 3.7, 4.5, 15.1% of CD8 + and 23, 59.3, 5.5% of CD4 + T cells, respectively. In the present study we demonstrated negative correlations between CD8 + CD28 + CD95 + and CD8 + CD28 − CD95 + T cells and both VCA IgM antibody titers and disease duration. However, no such correlation was found when subset of CD4 + T cells or CD8 + CD28 + CD95 − cells was compared. Conclusions We conclude that there is a rapid decrease in the number of memory CD8 + T cells in early acute stage of infectious mononucleosis. |
| Databáze: | OpenAIRE |
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