The prevalence of familial hypercholesterolemia in the West Siberian region of the Russian Federation: A substudy of the ESSE-RF

Autor: Olga Barbarash, Stepan S. Bazhan, A. Y. Efanov, Marina A. Storozhok, E. V. Indukaeva, Sergey Boytsov, Alexander D. Deev, I. V. Medvedeva, Svetlana A. Shalnova, Yana Danil'chenko, Olga K. Kuzmina, A. I. Ershova, Alexey N Meshkov
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Myocardial Infarction
lcsh:Medicine
Familial hypercholesterolemia
030204 cardiovascular system & hematology
Vascular Medicine
Russia
Coronary artery disease
Geographical Locations
Tendons
Cornea
0302 clinical medicine
Risk Factors
Epidemiology
Prevalence
Medicine and Health Sciences
Coronary Heart Disease
Myocardial infarction
Familial Hypercholesterolemia
lcsh:Science
education.field_of_study
Multidisciplinary
Anticholesteremic Agents
Drugs
Middle Aged
Europe
Genetic Diseases
Connective Tissue
Cohort
Female
Anatomy
Research Article
Adult
medicine.medical_specialty
Asia
Ocular Anatomy
Population
Cardiology
Hyperlipoproteinemia Type II
03 medical and health sciences
Diagnostic Medicine
Ocular System
Internal medicine
medicine
Humans
education
Clinical Genetics
Pharmacology
business.industry
Autosomal Dominant Diseases
lcsh:R
Statins
Biology and Life Sciences
Odds ratio
medicine.disease
Confidence interval
030104 developmental biology
Biological Tissue
People and Places
Physical therapy
lcsh:Q
business
Zdroj: PLoS ONE, Vol 12, Iss 7, p e0181148 (2017)
PLoS ONE
ISSN: 1932-6203
Popis: Background The prevalence of familial hypercholesterolemia (FH) in Russia has not previously been evaluated. The aim of our study was to investigate the prevalence of FH in the population of the West Siberian region of Russia, and then estimate the frequency of coronary artery disease (CAD) and treatment with cholesterol-lowering medication in FH patients. Methods The sample of our study consisted of participants from the population-based cohort of The Epidemiology of Cardiovascular Risk Factors and Diseases in Regions of the Russian Federation Study (ESSE-RF), conducted in the Tyumen and Kemerovo regions (1,630 and 1,622 people, respectively, aged 25–64). All participants who had LDL-cholesterol higher than 4.9 mmol/l and who had LDL-cholesterol less than or equal to 4.9 mmol/l but had statin therapy were examined and interviewed by experts in FH. Results The prevalence of patients with definite FH was 0.24% (one in 407) (95% confidence interval [CI]: 0.06%–0.42%), with probable FH was 0.68% (one in 148) (95% CI: 0.38%–0.98%), and with definite or probable FH combined was 0.92% (one in 108) (95% CI: 0.58%–1.26%). 40% (95% CI: 20.8%–59.2%) of patients with definite or probable FH had CAD. However, only 23% (95% CI: 6.3%–39.7%) of patients with definite or probable FH were on statins. The odds ratios for CAD and myocardial infarction (MI), adjusted for age, gender, region, smoking, hypertension, and diabetes mellitus, were 3.71 (95% CI: 1.58–8.72) (p = 0.003) and 4.06 (95% CI: 0.89–18.55) (р = 0.070) respectively for individuals with definite or probable FH relative to those who were unlikely to have FH. Conclusions The prevalence of FH in Russia may be significantly higher than previously estimated. There is underdiagnosis and undertreatment of FH in Russia.
Databáze: OpenAIRE
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