Safety and effects on the lipid and C-reactive protein plasma concentration of the association of ezetimibe plus atorvastatin in renal transplant patients treated by cyclosporine-A: a pilot study
| Autor: | G. Sbragia, D Taccola, Giuliano Barsotti, Vincenzo Panichi, Cristina Consani, Angelo Carpi, Sabrina Paoletti, Valentina Marchetti, G Manca-Rizza, E Mantuano |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Atorvastatin Renal function Pilot Projects Kidney Function Tests chemistry.chemical_compound Ezetimibe Internal medicine Humans Medicine Pyrroles Triglycerides Aged Pharmacology Kidney biology business.industry Cholesterol Anticholesteremic Agents C-reactive protein General Medicine Middle Aged Kidney Transplantation Lipids Hydroxymethylglutaryl-CoA reductase Transplantation Drug Combinations C-Reactive Protein medicine.anatomical_structure Endocrinology chemistry Heptanoic Acids Cyclosporine biology.protein Azetidines Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Immunosuppressive Agents medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 60:249-252 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2006.04.004 |
| Popis: | Ezetimibe (E) is a new cholesterol adsorption inhibitor which prevents the adsorption of dietary and biliary cholesterol by binding to a recently described cholesterol transporter. This pilot study was performed to evaluate the safety and the low-density lipoprotein (LDL)-C and C-reactive protein lowering efficacy of atorvastatin (A) and of the association of A plus E in five renal transplant patients with hypercholesterolemia and mild renal functional impairment receiving cyclosporine-A (CsA). Patients received for three periods, each of 3 weeks, A at a dose of 20 mg/day; A at a dose of 10 mg/day and finally, A 10 mg plus E 10 mg daily. The medications were well-tolerated and no important clinical or laboratory (muscle enzyme, creatinine clearance and CsA concentration) abnormalities were observed throughout the study period. A alone lead to target LDL-C values only in two of five patients and did not significantly reduce the mean CRP values. The combination of E plus A produced the lowest lipid levels and significantly reduced CRP mean values and allowed all patients to attain target levels of LDL-C: total cholesterol decreased from 240 +/- 42 (mean +/- S.D.) to 171 +/- 34 mg/dl, LDL-C from 129 +/- 32 to 87 +/- 21 mg/dl, plasma triglycerides from 330 +/- 54 to 194 +/- 71 mg/dl and CRP from 6.2 +/- 1.9 to 3.9 +/- 2.4 mg/l (P < 0.05 for all). This pilot study suggests that the co-administration of E and A at 10 mg/day in renal transplant patients receiving CsA is well-tolerated and effective in reducing important cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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