Niche Required for Inducing Quiescent Stem Cells
| Autor: | Rasmus Freter, S. Yonetani, Shin-Ichi Nishikawa, S. Torikai-Nishikawa, Masatake Osawa |
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| Rok vydání: | 2008 |
| Předmět: |
Niche
Mice Transgenic Biology Melanocyte Models Biological Resting Phase Cell Cycle Biochemistry Mice Gene expression Genetics medicine Animals Fibroblast Molecular Biology Cell Proliferation Gene Expression Profiling Stem Cells Mesenchymal stem cell Quiescent state Anatomy Hair follicle Cell biology Adult Stem Cells medicine.anatomical_structure Melanocytes Stem cell Hair Follicle |
| Zdroj: | Cold Spring Harbor Symposia on Quantitative Biology. 73:67-71 |
| ISSN: | 1943-4456 0091-7451 |
| DOI: | 10.1101/sqb.2008.73.024 |
| Popis: | Quiescence is an important feature distinguishing stem cells (SCs) from other compartments for most SC systems. Evidence suggests that the quiescent state is directed by external cues expressed in the presumptive microenvironment, the niche, although the cellular and molecular nature of the niche remains obscure in most SC systems. Our group has been addressing this question using the melanocyte (MC) as a model, because MC SCs (MSCs) and other compartments are distinguished by their location in the hair follicle, the former in the bulge and the other in the hair matrix. On the basis of the gene expression profiles of MSCs, we developed a method to distinguish MSCs from other compartments by using their own characteristics. Using the new criterion for MSCs, we investigated the molecular cues that induce the quiescent MSCs from proliferating melanoblasts. Our study showed that fibroblast growth factor-2 (FGF-2), or an equivalent signal, is essential for inducing a set of MSC signatures, although additional signals required for inducing the ultimate MSCs remain to be identified. |
| Databáze: | OpenAIRE |
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