The conglutination phenomenon. III. The conglutinating complement absorption test in experimental glanders
| Autor: | N. H. Hole, R. R. A. Coombs |
|---|---|
| Rok vydání: | 1947 |
| Předmět: |
biology
Epidemiology business.industry Pony Complement Fixation Tests Glanders Articles Haemolysis medicine.disease Complement fixation test Conglutinating Complement Absorption Test Titer Infectious Diseases Oral administration biology.animal Immunology Blood Group Antigens biology.protein Animals Medicine Horses Antibody business |
| Zdroj: | Epidemiology and Infection. 45:497-503 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0022172400014224 |
| Popis: | 1. Observations on the sera of ponies, taken at frequent intervals for 321 days after oral administration of P. mallei, are described.2. It was found that the conglutinating complement absorption test was more sensitive than the haemolytic complement fixation test as a means of diagnosis. It detected the antibodies earlier in the course of the disease and demonstrated their presence over a longer period of time.3. The possibility of another practical use of this reaction as an adjunct to the allergic test is considered. Ten days after an intradermo-palpebral test a pony, which had been previously sensitized and whose serum antibody titre at that time was below 10, developed a serum titre of over 160 as demonstrated by the conglutinating complement absorption test. Under similar circumstances 11 unsensitized ponies developed no detectable serum antibodies. |
| Databáze: | OpenAIRE |
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