Association of the OPRM1 and COMT genes’ polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?
Autor: | Isabelle Creveaux, Abdelbasset Amara, Leila Ben Fatma, Ali Saad, Sarah Langlais, Frédéric Libert, Moez Gribaa, Jean-Baptiste Woillard, Imen Chatti |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male Oncology medicine.medical_specialty Tunisia Adolescent Genotype medicine.drug_class Population Receptors Opioid mu Single-nucleotide polymorphism Pharmacology Catechol O-Methyltransferase Polymorphism Single Nucleotide Genetic Heterogeneity Young Adult 03 medical and health sciences 0302 clinical medicine Opioid receptor Internal medicine medicine Humans SNP Pharmacology (medical) education Aged education.field_of_study Morphine Genetic heterogeneity business.industry Haplotype Cancer Pain Middle Aged Analgesics Opioid Opioid 030220 oncology & carcinogenesis Female business 030217 neurology & neurosurgery medicine.drug rs4680 |
Zdroj: | Therapies. 71:507-513 |
ISSN: | 0040-5957 |
Popis: | Summary Background Genetic causes for inter-individual variability response to opioids are clinical difficulties for treatment efficiency. The aim of the present study was to investigate the possible association of opioid treatment outcome with single nucleotide polymorphisms (SNPs) in the mμ opioid receptor ( OPRM1 ) and catechol-o-methyltransferase ( COMT ) genes, in Tunisian cancer pain patients. Methods We genotyped one hundred and twenty-nine cancer patients treated with different doses of morphine for 3 SNPs in OPRM1 gene (rs17174629, rs1799972 and rs1799971) and one in the COMT gene (rs4680). Associations between dose (continuous), dose escalation (yes/no) and SNP or haplotypes were investigated. Results Unlike other studies on Caucasian and Chinese populations, no significant association were found between the 4 polymorphisms screened and the dose of morphine needed for pain relief. Conclusion This result can be explained by the genetic heterogeneity and cosmopolitan areas of our Tunisian patients compared to the others homogenous population. |
Databáze: | OpenAIRE |
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