The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat
| Autor: | Daniel Goula, Boldizsár Czéh, Eberhard Fuchs, Philipp von Rosenstiel, Osborne F. X. Almeida, Anja K Fischer |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Cell Survival chemistry.chemical_compound Glucocorticoid receptor Mineralocorticoid receptor Internal medicine medicine Animals Rats Wistar Receptor Molecular Biology Aldosterone Neurons Chemistry General Neuroscience Dentate gyrus Neurogenesis Adrenalectomy Granule cell Immunohistochemistry Rats medicine.anatomical_structure Endocrinology Receptors Mineralocorticoid Mineralocorticoid Dentate Gyrus Neurology (clinical) hormones hormone substitutes and hormone antagonists Developmental Biology |
| Zdroj: | Brain research. 947(2) |
| ISSN: | 0006-8993 |
| Popis: | Glucocorticoid receptor activation inhibits granule cell proliferation in the hippocampus, but little is known about the role of mineralocorticoid receptors in this process. Here we administered aldosterone to adrenalectomized (ADX) rats, and monitored neurogenesis by BrdU immunohistochemistry. ADX significantly increased the number of BrdU-positive cells and aldosterone replacement further augmented BrdU-positivity. Our results indicate that aldosterone, most probably acting through mineralocorticoid receptors, may positively influence the proliferation and survival of newly-generated granule cells. |
| Databáze: | OpenAIRE |
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