Treatment of Acute Myocardial Infarction With Sirolimus-Eluting Stents Results in Chronic Endothelial Dysfunction in the Infarct-Related Coronary Artery
| Autor: | Keita Sano, Yosuke Watanabe, Kazuhiro Watanabe, Kiyotaka Kugiyama, Takamitsu Nakamura, Toshiaki Yano, Tsuyoshi Kobayashi, Yukio Saitoh, Yasushi Kodama, Daisuke Fujioka, Jyun-ei Obata, Yoshinobu Kitta, Ken-ichi Kawabata |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Myocardial Infarction Myocardial Reperfusion Anterior Descending Coronary Artery Ventricular Dysfunction Left Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Endothelial dysfunction Aged Retrospective Studies Sirolimus Ejection fraction business.industry Stent Drug-Eluting Stents Stroke Volume Middle Aged medicine.disease Coronary Vessels Anti-Bacterial Agents Coronary arteries medicine.anatomical_structure Regional Blood Flow Drug-eluting stent Cardiology Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Circulation: Cardiovascular Interventions. 2:384-391 |
| ISSN: | 1941-7632 1941-7640 |
| DOI: | 10.1161/circinterventions.108.821371 |
| Popis: | Background— Sirolimus-eluting stent (SES) implantation aggravated endothelial vasomotor dysfunction in infarct-related coronary arteries. Methods and Results— This study examined the effect of SES implantation on the duration of reperfusion-induced endothelial vasomotor dysfunction in infarct-related coronary arteries and on postinfarct left ventricular dysfunction in acute myocardial infarction (AMI). Patients with a first AMI due to occlusion of the left anterior descending coronary artery and successful reperfusion using SES (n=15) or bare metal stents (BMS; n=18) were examined. The vasomotor response of the left anterior descending coronary artery to acetylcholine and left ventriculography were examined 2 weeks and 6 months after AMI. At 6 months after AMI, the impairment of epicardial coronary artery dilation and coronary blood flow increase in response to acetylcholine was recovered from 2 weeks after AMI in BMS-treated patients, whereas the responses of SES-treated patients improved but remained impaired compared with BMS-treated patients (% increase in blood flow, 77�12% in SES versus 116�15% in BMS at 10 μg/min of acetylcholine, P P Conclusions— SES implantation may delay recovery of reperfusion-induced endothelial vasomotor dysfunction in infarct-related coronary arteries and left ventricular regional dysfunction for at least 6 months after AMI. |
| Databáze: | OpenAIRE |
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