The generality of transient compartmentalization and its associated error thresholds

Autor: Luca Peliti, Philippe Nghe, Alex Blokhuis, David Lacoste
Přispěvatelé: Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Statistics and Probability
Mutation rate
Cell division
Error threshold
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
FOS: Physical sciences
Condensed Matter - Soft Condensed Matter
General Biochemistry
Genetics and Molecular Biology
82-XX
92Dxx
60J80
Diffusion
03 medical and health sciences
0302 clinical medicine
Mutation Rate
Physics - Biological Physics
Autocatalytic reaction
Quantitative Biology - Populations and Evolution
ComputingMilieux_MISCELLANEOUS
Physics
Generality
General Immunology and Microbiology
Applied Mathematics
Populations and Evolution (q-bio.PE)
General Medicine
RNA world hypothesis
030104 developmental biology
Biological Physics (physics.bio-ph)
FOS: Biological sciences
Modeling and Simulation
Mutation
Soft Condensed Matter (cond-mat.soft)
General Agricultural and Biological Sciences
Biological system
030217 neurology & neurosurgery
Zdroj: Journal of Theoretical Biology
Journal of Theoretical Biology, Elsevier, 2020, 487, pp.110110. ⟨10.1016/j.jtbi.2019.110110⟩
ISSN: 0022-5193
1095-8541
DOI: 10.1016/j.jtbi.2019.110110⟩
Popis: Can prelife proceed without cell division? A recently proposed mechanism suggests that transient compartmentalization could have preceded cell division in prebiotic scenarios. Here, we study transient compartmentalization dynamics in the presence of mutations and noise in replication, as both can be detrimental the survival of compartments. Our study comprises situations where compartments contain uncoupled autocatalytic reactions feeding on a common resource, and systems based on RNA molecules copied by replicases, following a recent experimental study. Using the theory of branching processes, we show analytically that two regimes are possible. In the diffusion-limited regime, replication is asynchronous which leads to a large variability in the composition of compartments. In contrast, in a replication-limited regime, the growth is synchronous and thus the compositional variability is low. Typically, simple autocatalysts are in the former regime, while polymeric replicators can access the latter. For deterministic growth dynamics, we introduce mutations that turn functional replicators into parasites. We derive the phase boundary separating coexistence or parasite dominance as a function of relative growth, inoculation size and mutation rate. We show that transient compartmentalization allows coexistence beyond the classical error threshold, above which the parasite dominates. Our findings invite to revisit major prebiotic transitions, notably the transitions towards cooperation, complex polymers and cell division.
37 pages, 13 figures
Databáze: OpenAIRE
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