Pharmacokinetics of a single, large dose of cholecalciferol
| Autor: | Marium Ilahi, Robert P. Heaney, Laura A.G. Armas |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Radioimmunoassay Medicine (miscellaneous) Skin Pigmentation Gastroenterology White People Cohort Studies chemistry.chemical_compound Pharmacokinetics Internal medicine medicine Vitamin D and neurology Animals Humans Dosing Vitamin D Aged Cholecalciferol Aged 80 and over Nutrition and Dietetics Bone Density Conservation Agents Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Vitamin D Deficiency Dose–response relationship Endocrinology Milk chemistry Area Under Curve Dietary Supplements Sunlight Patient Compliance Calcifediol Female Seasons business Kidney disease |
| Zdroj: | The American journal of clinical nutrition. 87(3) |
| ISSN: | 1938-3207 |
| Popis: | BACKGROUND There is much interest in dosing vitamin D intermittently for patient convenience and long-term adherence. OBJECTIVE The objective was to characterize the time course and response of 25-hydroxyvitamin D (calcidiol) to a large oral dose of cholecalciferol. DESIGN One group (30 subjects) was supplemented with a single oral dose of 100,000 IU cholecalciferol. A second group (10 subjects) served as a control group to assess the seasonal change of calcidiol. Serum calcidiol concentrations were followed for 4 mo. The subjects were healthy with limited sun exposure ( |
| Databáze: | OpenAIRE |
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