Efficacy and tolerability on melasma of a topical cosmetic product acting on melanocytes, fibroblasts and endothelial cells: a randomized comparative trial against 4% hydroquinone
| Autor: | K.T. Fook Chong, P. Faure, Thierry Passeron, E. Bronzina, A. Clement, B. Marie |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Melasma Administration Topical Skin Pigmentation Cosmetics Dermatology Melanosis Melanin 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Depigmentation Double-Blind Method Surveys and Questionnaires medicine Humans Pigmentary Disorders Hydroquinone business.industry Significant difference Endothelial Cells Fibroblasts Middle Aged Comparative trial medicine.disease Pathophysiology Hydroquinones 030104 developmental biology Infectious Diseases chemistry Tolerability Patient Satisfaction Melanocytes Original Article Female medicine.symptom business Sunscreening Agents |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology |
| ISSN: | 1468-3083 0926-9959 |
| DOI: | 10.1111/jdv.16150 |
| Popis: | Background Recent data demonstrated that an altered basal membrane, activated melanocytes and secreted factors from keratinocytes but also fibroblasts and endothelial cells are involved in the pathophysiology of melasma. Objectives To evaluate the efficacy and tolerability on melasma of a new topical skin‐lightening cosmetic product combination (CCP) targeting several factors identified to be involved in melasma pathogenesis compared to 4% hydroquinone (HQ). Methods Forty‐three women with melasma were enrolled in a 12‐week double‐blind, randomized, parallel‐group trial and treated with CCP or 4% HQ cream. Efficacy was evaluated with the modified Melasma Area Severity Index (mMASI) score and colorimetric change. Cutaneous tolerability and patient satisfaction were also investigated. Results The mMASI score decreased for both products from baseline and over the study period. At week 12, 90% of the subjects who received the combination products had an improvement in pigmentation vs. 79% with HQ. Similarly, both products significantly increased Individual Typological Angle parameters. For both measures, no statistically significant difference was observed between CCP and HQ in terms of change from baseline. CPP was very well tolerated. Conclusions Cosmetic product combination is as effective as HQ in the management of facial dyspigmentation and represents a safe alternative. |
| Databáze: | OpenAIRE |
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