Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl)thio)naphthalene-1,4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory effect in colon cancer cell line

Autor:	Emerson Lucena da Silva, Felipe Pantoja Mesquita, Ingryd Nayara de Farias Ramos, Carinne Borges de Souza Moraes Rego Gomes, Caroline dos Santos Moreira, Vítor Francisco Ferreira, David Rodrigues da Rocha, Marcelo de Oliveira Bahia, Caroline Aquino Moreira-Nunes, Carolina Rosal Teixeira de Souza, Rommel Mario Rodrigues Burbano, Raquel Carvalho Montenegro
Rok vydání:	2022
Předmět:	Pharmacology Membrane Potential Mitochondrial Cell Survival Cell Line Tumor Colonic Neoplasms Humans Antineoplastic Agents Apoptosis Naphthalenes Toxicology Reactive Oxygen Species Cell Line DNA Damage
Zdroj:	Toxicology and applied pharmacology. 456
ISSN:	1096-0333
Popis:	Colorectal cancer (CRC) is estimated as the third most incident cancer and second in mortality worldwide. Moreover, CRC metastasis reduces patients' survival rates. Thus, the study and identification of new compounds with anticancer activity selectively to tumor cells are encouraged in the CRC treatment. Naphtoquinones are compounds with several pharmacologic activities, including antitumoral properties. Therefore, this study aimed to investigate the anticancer mechanism of synthetic 8-Hydroxy-2-(P-Nitrothiophenol)-1,4-Naphthoquinone (CNN16) in colon cancer cell line HCT-116. CNN16 showed an IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a42d240182ca7b3fd3f466d34179f9f https://pubmed.ncbi.nlm.nih.gov/36208702 Zobrazit plný text záznamu Full Text from ScienceDirect