Clinical Pharmacology of Mivacurium Chloride (BW B1090U) in Children During Nitrous Oxide-Halothane and Nitrous Oxide-Narcotic Anesthesia
| Autor: | J B Sarner, David R. Cook, Barbara W. Brandom, McNulty Bf, V. J. Foster, M. L. Dong, S. K. Woelfel, M. Horn |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Narcotics
medicine.medical_specialty Mean arterial pressure Narcotic medicine.medical_treatment Nitrous Oxide Neuromuscular transmission Mivacurium chloride Heart rate medicine Humans Anesthesia Child Dose-Response Relationship Drug business.industry Age Factors Hemodynamics Isoquinolines Adductor pollicis muscle Surgery Mivacurium Anesthesiology and Pain Medicine Child Preschool Anesthetic Halothane business Half-Life Neuromuscular Nondepolarizing Agents medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 68:116-121 |
| ISSN: | 0003-2999 |
| DOI: | 10.1213/00000539-198902000-00009 |
| Popis: | We determined the dose-response relationships of mivacurium (BW B1090U) in children (2-10 years) during nitrous oxide-halothane anesthesia (0.8% end-tidal) and during nitrous oxide-narcotic anesthesia. Neuromuscular blockade was monitored by recording the electromyographic activity of the adductor pollicis muscle resulting from supramaximal stimulation at the ulnar nerve at 2 Hz for 2 seconds at 10-second intervals. To estimate dose-response relationships, for each anesthetic background four subgroups of nine patients received single bolus doses of 20-120 micrograms/kg mivacurium. The ED50 and ED95 (estimated from linear regression plots of log-dose vs. probit of effect) were 52 micrograms/kg and 89 micrograms/kg during halothane anesthesia and 62 micrograms/kg and 103 micrograms/kg during narcotic anesthesia. Nine additional patients in each anesthetic group received 250 micrograms/kg mivacurium. Three of the 18 patients given 250 micrograms/kg mivacurium developed cutaneous flushing; in one of these mean arterial pressure decreased 32% for less than 1 minute; no significant changes in heart rate occurred. With the increase in mivacurium dose from 120 micrograms/kg to 250 micrograms/kg the times to onset of 90% and maximum neuromuscular block decreased by 0.5 to 1 minute, and the times to recovery of neuromuscular transmission to 5% (T5) or 25% (T25) increased by 2-4 minutes. The recovery index (T25-75) in patients anesthetized with halothane was 4.3 +/- 1.5 minute (mean +/- SD); the time to complete recovery (T4:1 greater than or equal to 0.75) was 19.8 +/- 7.4 minutes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|