Treatment of Alzheimerʼs Disease with Sabeluzole
| Autor: | Erich Mohr, Bruce A. Pappas, Gary Belanger, Susan Murtha, Tilak Mendis, Margaret Sampson, N. P. V. Nair |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_treatment Central nervous system Disease Pharmacology Placebo Central nervous system disease chemistry.chemical_compound Cognition Degenerative disease Double-Blind Method Piperidines Alzheimer Disease Image Processing Computer-Assisted medicine Humans Pharmacology (medical) Aged Psychiatric Status Rating Scales Chemotherapy business.industry Brain Middle Aged medicine.disease Thiazoles medicine.anatomical_structure chemistry Sabeluzole Female Neurology (clinical) Alzheimer's disease Tomography X-Ray Computed business Neuroscience |
| Zdroj: | Clinical Neuropharmacology. 20:338-345 |
| ISSN: | 0362-5664 |
| DOI: | 10.1097/00002826-199708000-00005 |
| Popis: | Sabeluzole, a new benzothiazole derivative, has been shown to be neurobiologically active preclinically and clinically appears to exert beneficial effects on memory. In this study, sabeluzole (5 or 10 mg twice daily vs. placebo) was investigated in patients with probable Alzheimer's disease over 1 year, with assessments of cognitive performance and structural changes. Cognitive performance was measured using the Alzheimer's Disease Assessment Scale periodically during treatment. Potential structural correlates in the frontal horn, caudate, third ventricle and hippocampal regions were examined by obtaining computerized tomographic (CT) images before and after treatment. Patients receiving sabeluzole evidenced greater stability than did placebo-treated patients in some cognitive measures. CT measures showed no significant changes from baseline, but some weak associations were found between relative preservation of cognitive function and smaller structural declines in the third ventricle and hippocampus. Cognitive outcome measures suggest that sabeluzole may have potential in slowing the cognitive deterioration of Alzheimer's disease. Furthermore, the method used to explore potential benefits on a morphologic level, although negative in this study, could yet have potential. |
| Databáze: | OpenAIRE |
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