Frequency and prognostic relevance of disseminated tumor cells in bone marrow of patients with metastatic renal cell carcinoma
| Autor: | Rainer Riesenberg, Ines Kotter, Alexander Buchner, Ralph Oberneder, Christian Stief, Alfons Hofstetter |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Metastasis Cytokeratin Renal cell carcinoma Biomarkers Tumor Carcinoma Humans Medicine Carcinoma Renal Cell Aged Aged 80 and over business.industry Micrometastasis Cancer Middle Aged Neoplastic Cells Circulating Prognosis medicine.disease Immunohistochemistry Survival Analysis Kidney Neoplasms medicine.anatomical_structure Oncology Case-Control Studies Keratins Female Bone marrow Bone Marrow Neoplasms business |
| Zdroj: | Cancer. 106:1514-1520 |
| ISSN: | 1097-0142 0008-543X |
| Popis: | BACKGROUND The prognostic relevance of disseminated cytokeratin-positive (CK+) tumor cells in the bone marrow of patients with different types of carcinoma has been demonstrated in several studies. In this prospective study, the frequency and prognostic value of CK+ tumor cells was investigated in the bone marrow of 55 consecutive patients with metastatic renal cell carcinoma (M1 RCC) in comparison with 256 M0 RCC patients from a previous study. METHODS Aspiration of bone marrow from the anterior iliac crest was performed immediately before tumor resection in RCC patients. Cytospins were made and stained by immunocytochemistry using the APAAP (alkaline phosphatase-antialkaline phosphatase) protocol and monoclonal antibodies CK2 and A45-B/B3. Twenty-seven patients with no evidence of any malignant disease served as a control group. RESULTS CK+ tumor cells were detected in 42% (23 of 55 patients) of the M1 patients and 25% (63 of 256 patients) of the M0 patients (P |
| Databáze: | OpenAIRE |
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