Serum citrulline as a diagnostic marker of sepsis-induced intestinal dysfunction
| Autor: | Hai-Rong Wu, Tao Xiao, Xi-Ping Wu, Qian Wang, Yun-Yan Guan, Jin-Gui Wang, Li-Juan Shen, Liang Wang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Rat model Group A Group B Sepsis Rats Sprague-Dawley chemistry.chemical_compound Internal medicine Citrulline Medicine Animals Hepatology business.industry Gastroenterology Diagnostic marker medicine.disease Normal group Rats Glutamine Intestinal Diseases Endocrinology chemistry Immunology business Biomarkers |
| Zdroj: | Clinics and research in hepatology and gastroenterology. 39(2) |
| ISSN: | 2210-741X |
| Popis: | Summary Objective To investigate the use of citrulline as an indicator for diagnosing septic acute intestinal dysfunction (SAID) in a rat model. Methods SD rats were divided into three groups: a normal group (A), a model group (B), and a glutamine group (C). Group B was divided into a 36-h group (B1) and a 72-h feeding group (B2). The concentrations of serum citrulline, intestinal fatty acid-binding protein (I-FABP) and intestinal glutamine and histopathological changes were measured. Results The lengths of the villus and thicknesses of the mucosal layer in groups B1, B2 and C were significantly different from those in group A. Citrulline concentrations in groups B1, B2 and C were lower than in group A; the serum concentrations in group C were significantly greater than in groups B1 and B2. The I-FABP levels of groups B1, B2 and C were higher than group A; I-FABP levels of groups B1 and B2 were higher than group C. Intestinal glutamine levels of groups B1 and B2 were lower than groups A and C. The serum citrulline of group C was negatively correlated with I-FABP and Chiu's score. Conclusions Serum citrulline could be used as the diagnostic indicator of SAID. |
| Databáze: | OpenAIRE |
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