In vitro activities of cefotaxime, ceftriaxone, ceftazidime, cefpirome, and penicillin against Streptococcus pneumoniae isolates
| Autor: | S. D. Brown, Arthur L. Barry, W. J. Novick |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cefotaxime
medicine.drug_class Cephalosporin Ceftazidime Microbial Sensitivity Tests Penicillins medicine.disease_cause Microbiology Streptococcus pneumoniae polycyclic compounds Medicine Pharmacology (medical) Antibacterial agent Pharmacology business.industry Ceftriaxone Cefpirome Cephalosporins Penicillin Infectious Diseases business medicine.drug Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 39(10) |
| ISSN: | 0066-4804 |
| Popis: | The in vitro activities of four extended-spectrum cephalosporins and benzyl penicillin were evaluated against 698 clinical isolates of Streptococcus pneumoniae, including 130 (19%) penicillin-intermediate and 84 (12%) penicillin-resistant strains. Cefotaxime and ceftriaxone were essentially identical in their antipneumococcal activities: both were active against penicillin-susceptible strains and most penicillin-intermediate strains. Cefpirome was twice as potent as cefotaxime and ceftriaxone against penicillin-resistant strains. Ceftazidime was 8- to 16-fold less active than cefotaxime and ceftriaxone against S. pneumoniae in vitro, and thus, its spectrum included only penicillin-susceptible strains. |
| Databáze: | OpenAIRE |
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