Enhancing effect of dietary oil emulsions on immune responses to protein antigens fed to mice
| Autor: | Masashi Nagata, Tetsuo Kaneko, Tamotsu Kuwata, Yukiko Senoo, Yuka Terasawa |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
food.ingredient
Immunology Mice Nude Milk allergy Lactoglobulins medicine.disease_cause Soybean oil Immune tolerance Mice food Allergen Immune system Antigen Immunopathology medicine Immunology and Allergy Animals Particle Size Mice Inbred BALB C Mice Inbred C3H biology Dose-Response Relationship Drug food and beverages General Medicine medicine.disease Soybean Oil Mice Inbred C57BL Immunoglobulin G biology.protein Emulsions Immunization Antibody |
| Zdroj: | International archives of allergy and immunology. 121(4) |
| ISSN: | 1018-2438 |
| Popis: | Repeated intragastric administration of β-lactoglobulin (β-Lg) with emulsified soybean oil elicited an antigen-specific, systemic humoral immune response in different strains of mice. The antibody response was enhanced as the dose of oil was increased and the particle size of emulsions was decreased. Feeding of aqueous β-Lg could induce the antibody response only when emulsified oil was fed almost simultaneously. However, the emulsion-driven humoral immune response was not observed when mice were treated with anti-CD40 ligand antibody or in athymic mice. It is likely that the intestinal coexistence of emulsified oil with dietary antigens modulates the immune system to crucially support B cell response. A practical application of the present results to the prevention of cow’s milk protein sensitization in infants is proposed. |
| Databáze: | OpenAIRE |
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