Ribosomal tunnel and translation regulation
| Autor: | Natalia V. Sumbatyan, Galina A. Korshunova, A. V. Shishkina, V. V. Karpenko, Alexei A. Bogdanov |
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| Rok vydání: | 2011 |
| Předmět: |
Peptidyl transferase
Protein Conformation General Medicine Biology Ribosomal RNA Biochemistry Ribosome Macrolide binding Cell biology Anti-Bacterial Agents Folding (chemistry) 23S ribosomal RNA Protein Biosynthesis Translational regulation Peptidyl Transferases biology.protein Animals Humans Macrolides Peptides Ribosomes 50S |
| Zdroj: | Biochemistry. Biokhimiia. 75(13) |
| ISSN: | 1608-3040 |
| Popis: | This review describes the results of recent studies of the ribosomal tunnel (RT), the major function of which is to allow the smooth passage of nascent polypeptides with different sequences from the peptidyl transferase center of the ribosome to the tunnel exit, where the folding of protein molecules begins. The features of structural organization of RT and their role in modulation and stabilization of the nascent chain conformation are discussed. Structural features of macrolide binding sites as well as application of macrolide antibiotics and their derivatives as tools to investigate ligand-tunnel wall interactions are also considered. Several examples of strong and specific interactions of regulatory polypeptides with nucleotide and amino acid residues of RT that lead to ribosome stalling and translational arrest are described in detail. The role of these events in regulation of expression of certain genes is discussed on the basis of recent high-resolution structural studies of nascent chains in the RT. |
| Databáze: | OpenAIRE |
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