Regulation of N-Myc downstream regulated gene 2 by bile acids
| Autor: | Pedro F. Marrero, Joan C. Rodríguez, Diego Haro, Cédric Langhi, Elena Pedraz-Cuesta, Yolanda Donate |
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| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2013 |
| Předmět: |
Male
Àcids biliars medicine.drug_class Biophysics Ronyó Receptors Cytoplasmic and Nuclear Nuclear receptors (Biochemistry) Biology Kidney Biochemistry Bile Acids and Salts Mice chemistry.chemical_compound Cell Line Tumor Chenodeoxycholic acid Regulació genètica medicine Gene Knockdown Techniques Animals Humans Càncer Molecular Biology Gene Adaptor Proteins Signal Transducing Cancer Mice Knockout Regulation of gene expression Gene knockdown Genetic regulation Bile acid Tumor Suppressor Proteins Proteins Hep G2 Cells Cell Biology Metabolisme Bile acids Up-Regulation Cell biology Gene Expression Regulation Neoplastic Mice Inbred C57BL Metabolism chemistry Nuclear receptor Receptors nuclears (Bioquímica) Farnesoid X receptor Proteïnes |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| Popis: | Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes. Knockdown of FXR abolished the induction by CDCA, whereas overexpre ssion of a constitutively active form of FXR increased NDRG2 expression. A FXR-response element was identified within intronic regions of human and murine genes. Moreover, mice given GW4064 exhib it an increase of Ndrg2 expression in liver and kidney, where both NDRG2 and FXR are enriched. The identification of NDRG2 as a bile acid regulated gene may provide novel knowledge toward the understanding of NDRG2 physiological function and the link between metabolism and cancer. |
| Databáze: | OpenAIRE |
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