Structural and functional properties of plant mitochondrial F-ATP synthase
| Autor: | Enrico Braidot, Antonio Filippi, Giovanna Lippe, Marco Zancani |
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| Rok vydání: | 2020 |
| Předmět: |
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Molecular 0301 basic medicine Protein Conformation PTP Mitochondrion Stress F-ATP synthase Gene Expression Regulation Enzymologic 03 medical and health sciences 0302 clinical medicine Stress Physiological Inner membrane Complex V Electrochemical gradient Inner mitochondrial membrane Molecular Biology Plant Proteins ATP synthase biology Chemistry Cell Biology Plants Electron transport chain Mitochondria Cell biology ATP Plant mitochondria Chloroplast Proton-Translocating ATPases Dimer 030104 developmental biology Mitochondrial matrix biology.protein Molecular Medicine 030217 neurology & neurosurgery |
| Zdroj: | Mitochondrion. 53:178-193 |
| ISSN: | 1567-7249 |
| Popis: | The mitochondrial F-ATP synthase is responsible for coupling the transmembrane proton gradient, generated through the inner membrane by the electron transport chain, to the synthesis of ATP. This enzyme shares a basic architecture with the prokaryotic and chloroplast ones, since it is composed of a catalytic head (F1), located in the mitochondrial matrix, a membrane-bound part (FO), together with a central and a peripheral stalk. In this review we compare the structural and functional properties of F-ATP synthase in plant mitochondria with those of yeast and mammals. We also present the physiological impact of the alteration of F-ATP synthase in plants, with a special regard to its involvement in cytoplasmic male sterility. Furthermore, we show the involvement of this enzyme in plant stress responses. Finally, we discuss the role of F-ATP synthase in shaping the curvature of the mitochondrial inner membrane and in permeability transition pore formation. |
| Databáze: | OpenAIRE |
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