Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children
| Autor: | Renee Margossian, Steven E. Lipshultz, Russell B. Van Dyke, Armando J. Mendez, Paige L. Williams, James D. Wilkinson, Wendy Yu, Justin P. Zachariah, William T. Shearer, Steven D. Colan |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
Male Serum medicine.medical_specialty Adolescent medicine.drug_class Immunology Human immunodeficiency virus (HIV) HIV Infections 030204 cardiovascular system & hematology medicine.disease_cause Severity of Illness Index Article 03 medical and health sciences 0302 clinical medicine Troponin T Hiv infected Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Immunology and Allergy Humans 030212 general & internal medicine Prospective Studies Protein Precursors Child Inflammation business.industry Interleukin Environmental Exposure Inflammatory biomarkers Antiretroviral therapy Healthy Volunteers Infectious Diseases C-Reactive Protein Cross-Sectional Studies Cardiovascular Diseases Echocardiography Biomarker (medicine) Cytokines Tumor necrosis factor alpha Female Cardiology and Cardiovascular Medicine business Biomarkers Cohort study |
| Zdroj: | AIDS (London, England). 32(10) |
| ISSN: | 1473-5571 |
| Popis: | OBJECTIVES: To compare distributions of serum cardiac and inflammatory biomarkers between perinatally HIV-infected (PHIV) and perinatally HIV-exposed uninfected (PHEU) children, to evaluate their associations with echocardiographic measures, and among PHIV youth, with antiretroviral therapy (ART) and HIV disease severity measures. DESIGN: Cross-sectional analysis of temporally-paired serum samples for biomarkers and echocardiograms in a prospective cohort study of PHIV and PHEU youth at 14 US pediatric HIV clinics. METHODS: Serum samples were analyzed among 402 youth in the PHACS Adolescent Master Protocol (AMP) for high-sensitivity cardiac troponin-T (hs-cTnT, a cardiomyocyte injury marker), NT-pro-brain natriuretic peptide (NT-proBNP, a myocardial stress marker), and inflammatory markers (high-sensitivity C-reactive protein, interleukin [IL]-1, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor-α[TNF-α], and soluble TNF receptor II [sTNF-RII]). Echocardiograms were centrally measured and parameters converted to Z-scores to account for differences in age and body size. RESULTS: Compared to PHEU (N=156), PHIV youth (N=246) more often had detectable hs-cTnT and higher levels of sTNF-RII and IL-18. Higher inflammatory biomarkers were generally associated with higher left ventricular (LV) wall stress and lower LV function and LV mass in the two groups. Among PHIV youth, the biomarkers were more strongly associated with current rather than historical immunologic and virologic status. CONCLUSIONS: PHEU and PHIV have modest, significant differences in serum levels of specific inflammatory and active myocardial injury biomarkers. Higher biomarker levels were associated with lower LV mass and shifts in LV structure. Further study is warranted on the longitudinal role of cardiac and inflammatory biomarkers for targeting interventions among PHIV and PHEU youth. |
| Databáze: | OpenAIRE |
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