Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury
| Autor: | Ulrika Wilhelmsson, Ralf Kühn, Alexandra Abramsson, Josefina Stakeberg, Milos Pekny, Maria Enge, Christer Betsholtz |
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| Rok vydání: | 2003 |
| Předmět: |
Central nervous system
Hippocampus Biochemistry Neuroprotection Cellular and Molecular Neuroscience Mice Cortex (anatomy) medicine Animals RNA Messenger DNA Primers Cerebral Cortex Neurons biology Base Sequence General Medicine Proto-Oncogene Proteins c-sis medicine.anatomical_structure nervous system Astrocytes Forebrain biology.protein Neuron Neuroscience Platelet-derived growth factor receptor Neurotrophin |
| Zdroj: | Neurochemical research. 28(2) |
| ISSN: | 0364-3190 |
| Popis: | Members of the PDGF family have multiple roles during embryogenesis and in a variety of pathological situations in the adult. One of the major sites of PDGF-B expression in adult mammals are postmitotic CNS neurons. Combined with reported neurotrophic and neuroprotective effects of exogenously administered PDGFs, this has led to the speculation that PDGF-B may have a role in CNS development, in maintenance, or in response to CNS injury. To test these hypotheses, we developed mice in which PDGF-B was ablated genetically in postmitotic neurons at sites where PDGF-B is normally expressed. We found that these mice develop to adulthood without apparent defects. We demonstrate PDGF-B expression in the postnatal mouse hippocampus and forebrain cortex. We show that neuron-specific knockout of PDGF-B does not influence the astroglial and angiogenic responses to injury in the hippocampus or forebrain cortex. We conclude that the role of neuron-derived PDGF-B remains obscure. A role for neuron-derived PDGF-B, if existing, might be redundant with other CNS growth factors. Alternatively, other and more specific analyses of CNS functions in the normal and injured states will be required to demonstrate such a role. |
| Databáze: | OpenAIRE |
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